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Brain Control with Light

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Watson Lecture Preview
News Writer: 
Douglas Smith
Viviana Gradinaru (BS '05) might one day be getting inside your head—but in a good way. An assistant professor of biology at Caltech, Gradinaru is trying to map out the brain's wiring diagrams. Gradinaru will discuss her work at 8:00 p.m. on Wednesday, December 5 in Caltech's Beckman Auditorium. Admission is free.

Social Synchronicity

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New Caltech-led research finds a connection between bonding and matched movements
News Writer: 
Katie Neith
Humans have a tendency to spontaneously synchronize their movements. For example, the footsteps of two friends walking together may synchronize, although neither individual is consciously aware that it is happening. Similarly, the clapping hands of an audience will naturally fall into synch. Although this type of synchronous body movement has been observed widely, its neurological mechanism and its role in social interactions remain obscure. A new study, led by cognitive neuroscientists at the California Institute of Technology (Caltech), has found that body-movement synchronization between two participants increases following a short session of cooperative training, suggesting that our ability to synchronize body movements is a measurable indicator of social interaction.

Research Update: Wordy Worms and Their Eavesdropping Predators

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News Writer: 
Katie Neith
Nematodes are trapped in the sticky web of a worm-eating fungus.
Credit: Sternberg Lab / Caltech
For over 25 years, Paul Sternberg has been studying worms—how they develop, why they sleep, and, more recently, how they communicate. Now, he has flipped the script a bit by taking a closer look at how predatory fungi may be tapping into worm conversations to gain clues about their whereabouts.

Sorting Out Stroking Sensations

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Caltech biologists find individual neurons in the skin that react to massage
News Writer: 
Katie Neith
This graph represents a quantitative readout of the increases in fluorescence measured with the microscope as a stroke stimulus was applied to the animal's skin. Vertical yellow bars indicate periods when the stroke stimulus is applied and peaks in fluorescence coincide with the delivery of the stroke stimulus.
Credit: Anderson Lab / Caltech
The skin is a human being's largest sensory organ, helping to distinguish between a pleasant contact, like a caress, and a negative sensation, like a pinch or a burn. Previous studies have shown that these sensations are carried to the brain by different types of sensory neurons that have nerve endings in the skin. Only a few of those neuron types have been identified, however, and most of those detect painful stimuli. Now biologists at the California Institute of Technology (Caltech) have identified in mice a specific class of skin sensory neurons that reacts to an apparently pleasurable stimulus.

Visualizing Biological Networks in 4D

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A unique microscope invented at Caltech captures the motion of DNA structures in space and time
News Writer: 
Katie Neith
A DNA structure as seen through the 4D electron microscope invented at Caltech.
Credit: Zewail & Lorenz/Caltech
Every great structure, from the Empire State Building to the Golden Gate Bridge, depends on specific mechanical properties to remain strong and reliable. Rigidity—a material's stiffness—is of particular importance for maintaining the robust functionality of everything from colossal edifices to the tiniest of nanoscale structures. In biological nanostructures, like DNA networks, it has been difficult to measure this stiffness, which is essential to their properties and functions. But scientists at the California Institute of Technology (Caltech) have recently developed techniques for visualizing the behavior of biological nanostructures in both space and time, allowing them to directly measure stiffness and map its variation throughout the network.

Mayo Appointed to National Science Board

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News Writer: 
Katie Neith
President Barack Obama has appointed Stephen Mayo, Caltech's William K. Bowes Jr. Foundation Chair of the Division of Biology and Bren Professor of Biology and Chemistry, to the National Science Board, the governing body of the National Science Foundation.

The First Genetic-Linkage Map

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From the Caltech Archives
News Writer: 
Douglas Smith
Professor of Genetics Alfred H. Sturtevant in Caltech's fly room in February, 1949. Photo by Ross Madden, Black Star.
Credit: Caltech Archives
A hand-drawn map published 100 years ago held the first proof that chromosomes carry our genetic material.

Developing Our Sense of Smell

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Caltech biologists pinpoint the origin of olfactory nerve cells
News Writer: 
Katie Neith
Image of 2.5-um thick optical slice through the nose of a zebrafish embryo in which microvillous (green) cells also are stained with a neuronal marker (red) demonstrating their neuronal identify. Nuclei are stained in blue. Scale bar: 30 μm.
Credit: Courtesy of Ankur Saxena/Caltech
When our noses pick up a scent, whether the aroma of a sweet rose or the sweat of a stranger at the gym, two types of sensory neurons are at work in sensing that odor or pheromone. These sensory neurons are particularly interesting because they are the only neurons in our bodies that regenerate throughout adult life—as some of our olfactory neurons die, they are soon replaced by newborns. Just where those neurons come from in the first place has long perplexed developmental biologists. Previous hypotheses about the origin of these olfactory nerve cells have given credit to embryonic cells that develop into skin or into the central nervous system, where ear and eye sensory neurons, respectively, are known to originate. But biologists at the California Institute of Technology (Caltech) have now found that neural-crest stem cells—multipotent, migratory cells unique to vertebrates that give rise to many structures in the body such as facial bones and smooth muscle—also play a key role in building olfactory sensory neurons in the nose.

Caltech Senior Wins Gates Cambridge Scholarship

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News Writer: 
Kimm Fesenmaier

Catherine Bingchan Xie, a senior bioengineering major and English minor at Caltech, has been selected to receive a Gates Cambridge Scholarship, which will fund her graduate studies at the University of Cambridge for the next academic year. Xie, a Canadian citizen, is one of 51 new international recipients selected from a pool of more than 4,000 applicants based not only on intellectual ability, but also on leadership capacity and a commitment to improving the lives of others.

Fifty Years of Clearing the Skies

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A Milestone in Environmental Science
News Writer: 
Douglas Smith
In this 1948 photo of the Los Angeles Civic Center at the height of a smog attack, the buildings one block away are barely visible.
Credit: Los Angeles Times Photographic Archive, Department of Special Collections, Charles E. Young Research Library, UCLA
Ringed by mountains and capped by a temperature inversion that traps bad air, Los Angeles has had bouts of smog since the turn of the 20th century. An outbreak in 1903 rendered the skies so dark that many people mistook it for a solar eclipse. Angelenos might now be living in a state of perpetual midnight—assuming we could live here at all—were it not for the work of Caltech Professor of Bio-organic Chemistry Arie Jan Haagen-Smit. How he did it is told here largely in his own words, excerpted from Caltech's Engineering & Science magazine between 1950 and 1962. (See "Related Links" for the original articles.)

Decision Making and Quality Control in Early Moments of a Protein’s Life

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Watson Lecture Preview
News Writer: 
Douglas Smith
Professor of Chemistry Shu-ou Shan studies the gears and springs in the molecular machinery of life. She’ll be giving us a guided tour of the cellular assembly line at 8 p.m. on Wednesday, May 22, 2013 in Caltech’s Beckman Auditorium. Admission is free.

Keeping Stem Cells Strong

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Caltech biologists show that an RNA molecule protects stem cells during inflammation
News Writer: 
Katie Neith
Credit: Jimmy Zhao / Caltech
When infections occur in the body, stem cells in the blood often jump into action by multiplying and differentiating into mature immune cells that can fight off illness. But repeated infections and inflammation can deplete these cell populations, potentially leading to the development of serious blood conditions such as cancer. Now, a team of researchers led by biologists at the California Institute of Technology (Caltech) has found that, in mouse models, the molecule microRNA-146a (miR-146a) acts as a critical regulator and protector of blood-forming stem cells (called hematopoietic stem cells, or HSCs) during chronic inflammation, suggesting that a deficiency of miR-146a may be one important cause of blood cancers and bone marrow failure.

Beauty and the Brain: Electrical Stimulation of the Brain Makes You Perceive Faces as More Attractive

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Findings may lead to promising ways to treat and study neuropsychiatric disorders
News Writer: 
Marcus Woo

Beauty is in the eye of the beholder, and—as researchers have now shown—in the brain as well.

The researchers, led by scientists at the California Institute of Technology (Caltech), have used a well-known, noninvasive technique to electrically stimulate a specific region deep inside the brain previously thought to be inaccessible. The stimulation, the scientists say, caused volunteers to judge faces as more attractive than before their brains were stimulated.

A Stepping-Stone for Oxygen on Earth

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Caltech researchers find evidence of an early manganese-oxidizing photosystem
News Writer: 
Katie Neith
Caltech graduate student Jena Johnson examines a 2.415 billion-year-old rock in South Africa where evidence of an early manganese-oxidizing photosystem was found.
Credit: Caltech
For most terrestrial life on Earth, oxygen is necessary for survival. But the planet's atmosphere did not always contain this life-sustaining substance, and one of science's greatest mysteries is how and when oxygenic photosynthesis—the process responsible for producing oxygen on Earth through the splitting of water molecules—first began. Now, a team led by geobiologists at the California Institute of Technology (Caltech) has found evidence of a precursor photosystem involving manganese that predates cyanobacteria, the first group of organisms to release oxygen into the environment via photosynthesis.

New Research Sheds Light on M.O. of Unusual RNA Molecules

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News Writer: 
Kimm Fesenmaier
The Xist lncRNA (red) recruits proteins responsible for modifying chromatin architecture (green) across the X-chromosome. Xist and its associated proteins coat the entire X-chromosome, forming a distinctive compartment in the nucleus (blue).
Credit: Amy Pandya-Jones and Kathrin Plath

The genes that code for proteins—more than 20,000 in total—make up only about 1 percent of the complete human genome. That entire thing—not just the genes, but also genetic junk and all the rest—is coiled and folded up in any number of ways within the nucleus of each of our cells. Think, then, of the challenge that a protein or other molecule, like RNA, faces when searching through that material to locate a target gene.


A Secret to Making Macrophages

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Caltech researchers find a key in cell-cycle duration
News Writer: 
Kimm Fesenmaier
Blood progenitor cells differentiating in culture. The brightness of green indicates the amount of the regulatory protein PU.1 present. These images are from a time-lapse movie taken over the course of differentiation.
Credit: Hao Yuan Kueh, Michael Elowitz and Ellen Rothenberg/Caltech

Biologists at the California Institute of Technology (Caltech) have worked out the details of a mechanism that leads undifferentiated blood stem cells to become macrophages—immune cells that attack bacteria and other foreign pathogens. The process involves an unexpected cycle in which cell division slows, leading to an increased accumulation of a particular regulatory protein that in turn slows cell division further. The finding provides new insight into how stem cells are guided to generate one cell type as opposed to another.

A Home for the Microbiome

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Caltech biologists identify, for the first time, a mechanism by which beneficial bacteria reside and thrive in the gastrointestinal tract
News Writer: 
Katie Neith
A section of mouse colon is shown with gut bacteria (outlined in yellow) residing within the crypt channel.
Credit: Caltech / Mazmanian Lab
The human body is full of tiny microorganisms—hundreds to thousands of species of bacteria collectively called the microbiome, which are believed to contribute to a healthy existence. The gastrointestinal (GI) tract—and the colon in particular—is home to the largest concentration and highest diversity of bacterial species. But how do these organisms persist and thrive in a system that is constantly in flux due to foods and fluids moving through it? A team led by California Institute of Technology (Caltech) biologist Sarkis Mazmanian believes it has found the answer, at least in one common group of bacteria: a set of genes that promotes stable microbial colonization of the gut.

Team Led by Caltech Wins Second $10 Million Award for Research in Molecular Programming

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News Writer: 
Jessica Stoller-Conrad
Conceptual representation of programming languages for specifying molecular components and molecular systems, part of the Molecular Programming Project.
Credit: Lulu Qian, Caltech

During the past century, programmable technologies evolved from spinning gears and vacuum tubes to transistors and microchips. Now, a group of Caltech researchers and their colleagues at the University of Washington, Harvard University, and UC San Francisco are exploring how biologically important molecules—like DNA, RNA, and proteins—could be the next generation of programmable devices.

Caltech-led WormBase Project Awarded $14.8 Million by NIH

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News Writer: 
Kimm Fesenmaier
Rendering of the adult hermaphrodite worm species C. elegans with the outermost cuticle and hypodermis made transparent. Body wall muscles are shown in green. Neurons appear as pink, red, and purple lines wrapping around the muscle. Inside the muscle layer, portions of the reproductive system (purple and blue) and the intestine (pink) can be seen. The tan objects at the front and back of the worm are skin cells.
Credit: Chris Grove at WormBase, Caltech, http://caltech.wormbase.org/virtualworm
As many as 1 million nematode species are thought to live on Earth, and many are pests or parasites that ravage crops and spread diseases. They also happen to share many genes that are found in humans, and are intensively researched by labs around the world.

New Gut Bacterium Discovered in Termite's Digestion of Wood

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Caltech researchers find new species of microbe responsible for acetogenesis, an important process in termite nutrition.
News Writer: 
Jessica Stoller-Conrad
Phase contrast photomicrograph of a termite gut protozoan and attached symbiotic bacteria (small dark dots). Caltech researchers describe details of this association in the Sept. 16 edition of PNAS online.
Credit: Jared R. Leadbetter
When termites munch on wood, the small bits are delivered to feed a community of unique microbes living in their guts, and in a complex process involving multiple steps, these microbes turn the hard, fibrous material into a nutritious meal for the termite host. One key step uses hydrogen to convert carbon dioxide into organic carbon—a process called acetogenesis—but little is known about which gut bacteria play specific roles in the process.
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